A new and versatile on-line automated solid-phase approach to obtain cyclic PNA (I and III) and cyclic PNA-DNA chimeras (II) in highly pure form has been developed. Starting from a Tentagel matrix functionalized with a 3-chloro-4-hydroxyphenylacetic linker, the synthesis of representative, new cyclic molecules by standard peptide and phosphoramidite-based chemistry has been achieved.
Solid Phase Synthesis of cyclic PNA and PNA-DNA chimeras / L., M., DE NAPOLI, L., B., D.B., DI FABIO, G., J., D., Montesarchio, D., A., M.. - In: ORGANIC LETTERS. - ISSN 1523-7060. - ELETTRONICO. - 8:10(2006), pp. 2015-2018. [10.1021/ol0603559]
Solid Phase Synthesis of cyclic PNA and PNA-DNA chimeras
DE NAPOLI, LORENZO;DI FABIO, GIOVANNI;MONTESARCHIO, DANIELA;
2006
Abstract
A new and versatile on-line automated solid-phase approach to obtain cyclic PNA (I and III) and cyclic PNA-DNA chimeras (II) in highly pure form has been developed. Starting from a Tentagel matrix functionalized with a 3-chloro-4-hydroxyphenylacetic linker, the synthesis of representative, new cyclic molecules by standard peptide and phosphoramidite-based chemistry has been achieved.File in questo prodotto:
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