KRAS mutations drive pancreatic ductal adenocarcinoma (PDAC). In this issue of Developmental Cell , Salomó Coll et al. 1 reveal that KRAS suppresses endoplasmic reticulum (ER)-phagy in pancreatic acinar cells by inhibiting CCPG1 transcription. Impaired ER-phagy triggers protein aggregation, inflammation, and acinar-to-ductal metaplasia, promoting tumorigenesis. These findings highlight selective autophagy’s role in cancer, with possible therapeutic implications.
A matter of selectivity: ER-phagy suppression at the onset of pancreatic cancer / Settembre, Carmine. - In: DEVELOPMENTAL CELL. - ISSN 1534-5807. - 60:24(2025), pp. 3359-3360. [10.1016/j.devcel.2025.11.005]
A matter of selectivity: ER-phagy suppression at the onset of pancreatic cancer
Settembre, Carmine
2025
Abstract
KRAS mutations drive pancreatic ductal adenocarcinoma (PDAC). In this issue of Developmental Cell , Salomó Coll et al. 1 reveal that KRAS suppresses endoplasmic reticulum (ER)-phagy in pancreatic acinar cells by inhibiting CCPG1 transcription. Impaired ER-phagy triggers protein aggregation, inflammation, and acinar-to-ductal metaplasia, promoting tumorigenesis. These findings highlight selective autophagy’s role in cancer, with possible therapeutic implications.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
