Crystals of the model protein lysozyme were grown and soaked with the potential drug VIVO(acetylacetonato)2 at 37°C. X-ray diffraction and electron paramagnetic resonance (EPR) data collected at this temperature reveal that mixed-valence cage-like polyoxidovanadate clusters are formed and covalently bind protein residue side chains at physiological temperature.
Formation of Mixed-Valence Cage-Like Polyoxidovanadates at 37°C Upon Reaction of VIVO(acetylacetonato)2 With Lysozyme / Tito, G.; Ferraro, G.; Garribba, E.; Merlino, A.. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - 31:32(2025). [10.1002/chem.202500488]
Formation of Mixed-Valence Cage-Like Polyoxidovanadates at 37°C Upon Reaction of VIVO(acetylacetonato)2 With Lysozyme
Tito G.;Ferraro G.;Merlino A.
2025
Abstract
Crystals of the model protein lysozyme were grown and soaked with the potential drug VIVO(acetylacetonato)2 at 37°C. X-ray diffraction and electron paramagnetic resonance (EPR) data collected at this temperature reveal that mixed-valence cage-like polyoxidovanadate clusters are formed and covalently bind protein residue side chains at physiological temperature.File in questo prodotto:
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