The objective of this article is to provide the reader with a new paradigm of the biology of the adult human heart. The recognition that primitive undifferentiated cells and lineage-committed cells are present in the normal and stressed myocardium strongly suggests that the heart belongs to the group of self-renewing organs. Additionally, the expression of telomerase in amplifying myocytes is enhanced in the overloaded heart, supporting the notion that a significant growth reserve exists in the myocardium. Myocyte hypertrophy is no longer the only form of cell growth in the pathologic heart.
Myocyte growth in the failing heart / Kajstura, J; Leri, A; Castaldo, Clotilde; Nadal Ginard, B; Anversa, P.. - In: THE SURGICAL CLINICS OF NORTH AMERICA. - ISSN 0039-6109. - STAMPA. - 84:1(2004), pp. 161-177.
Myocyte growth in the failing heart
CASTALDO, CLOTILDE;
2004
Abstract
The objective of this article is to provide the reader with a new paradigm of the biology of the adult human heart. The recognition that primitive undifferentiated cells and lineage-committed cells are present in the normal and stressed myocardium strongly suggests that the heart belongs to the group of self-renewing organs. Additionally, the expression of telomerase in amplifying myocytes is enhanced in the overloaded heart, supporting the notion that a significant growth reserve exists in the myocardium. Myocyte hypertrophy is no longer the only form of cell growth in the pathologic heart.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
