Introduction: Trimethylamine N-oxide (TMAO) is a gut bacteria-dependent metabolite associated with poor cardiovascular health. Exercise is a known cardioprotective activity but the impact of an acute bout of exercise on TMAO production is unknown. Objectives/methods: This study assessed choline-derived production of TMAO following a single bout of intermittent exercise in a young, healthy cohort. Results: Choline supplemented after either exercise or a time-matched resting period demonstrated a similar increase in circulating TMAO across an 8-hour period. Conclusion: This suggests that a single bout of intermittent exercise does not alter gut microbial metabolic behaviour and thus does not provide additional cardioprotective benefits related to blood levels of TMAO.
Effect of an acute session of intermittent exercise on trimethylamine N-oxide (TMAO) production following choline ingestion / Ong, M. L. Y.; Green, C. G.; Rowland, S. N.; Rider, K.; Sutcliffe, H.; Funnell, M. P.; Salzano, A.; Heaney, L. M.. - In: METABOLOMICS. - ISSN 1573-3882. - 20:5(2024). [10.1007/s11306-024-02177-0]
Effect of an acute session of intermittent exercise on trimethylamine N-oxide (TMAO) production following choline ingestion
Salzano A.;
2024
Abstract
Introduction: Trimethylamine N-oxide (TMAO) is a gut bacteria-dependent metabolite associated with poor cardiovascular health. Exercise is a known cardioprotective activity but the impact of an acute bout of exercise on TMAO production is unknown. Objectives/methods: This study assessed choline-derived production of TMAO following a single bout of intermittent exercise in a young, healthy cohort. Results: Choline supplemented after either exercise or a time-matched resting period demonstrated a similar increase in circulating TMAO across an 8-hour period. Conclusion: This suggests that a single bout of intermittent exercise does not alter gut microbial metabolic behaviour and thus does not provide additional cardioprotective benefits related to blood levels of TMAO.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
