OBJECTIVE To assess the association between daily carbohydrate (CHO) entries and glycemic outcomes in youth with type 1 diabetes after automated insulin delivery (AID) initiation in real-life settings. RESEARCH DESIGN AND METHODS In this longitudinal, multinational observational study, 347 young individuals (7–21 years old) with type 1 diabetes for >1 year were followed for >6 months after AID initiation. Clinical data, including daily and overall continuous glucose monitoring–basedtimeinrange(TIR)(70–180 mg/dL), time in tight range (TITR) (70–140 mg/dL), and CHO entry metrics, were evaluated. RESULTS Day-to-day variability in CHO entries was negatively associated with overall TIR (P < 0.001) and TITR (P < 0.001). Higher deviation in daily CHO entry was associated with lower daily TITR and TIR (both P < 0.001). Overall TIR and TITR after AID initiation were 75.0% and 50.3%, respectively. CONCLUSIONS Variability in CHO entries is associated with lower TIR, emphasizing the importance of consistent premeal bolus routine when using AID.
Daily Carbohydrate Entries and Glycemic Outcomes Following Automated Insulin Delivery System Initiation in Youth With Type 1 Diabetes: A Real-World Multinational Longitudinal Study / Bombaci, Bruno; Hropot, Tim; Bratina, Natasa; Smigoc Schweiger, Darja; Passanisi, Stefano; Salzano, Giuseppina; Di Candia, Francesca; Lombardo, Fortunato; Battelino, Tadej; Dovc, Klemen. - In: DIABETES CARE. - ISSN 0149-5992. - 48:8(2025), pp. 1434-1437. [10.2337/dc25-0283]
Daily Carbohydrate Entries and Glycemic Outcomes Following Automated Insulin Delivery System Initiation in Youth With Type 1 Diabetes: A Real-World Multinational Longitudinal Study
Di Candia, FrancescaData Curation
;
2025
Abstract
OBJECTIVE To assess the association between daily carbohydrate (CHO) entries and glycemic outcomes in youth with type 1 diabetes after automated insulin delivery (AID) initiation in real-life settings. RESEARCH DESIGN AND METHODS In this longitudinal, multinational observational study, 347 young individuals (7–21 years old) with type 1 diabetes for >1 year were followed for >6 months after AID initiation. Clinical data, including daily and overall continuous glucose monitoring–basedtimeinrange(TIR)(70–180 mg/dL), time in tight range (TITR) (70–140 mg/dL), and CHO entry metrics, were evaluated. RESULTS Day-to-day variability in CHO entries was negatively associated with overall TIR (P < 0.001) and TITR (P < 0.001). Higher deviation in daily CHO entry was associated with lower daily TITR and TIR (both P < 0.001). Overall TIR and TITR after AID initiation were 75.0% and 50.3%, respectively. CONCLUSIONS Variability in CHO entries is associated with lower TIR, emphasizing the importance of consistent premeal bolus routine when using AID.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
