Regeneration of new periodontal attachment following surgical removal of a Peripheral Giant Cell Granuloma in a young patient: an 8-year follow-up

Background Peripheral Giant Cell Granuloma (PGCG) is a rare benign lesion of the oral cavity originating from periosteum and gingival connective tissue, associated to local irritant and/or traumatic factors. Clinically PGCG appears as a painless swelling lesion with a smooth surface, brown red or purple in colour, ranging from few millimeters to 3-4 centimeters. The aim of this case report is to demonstrate the complete periodontal and bone regeneration after elimination of traumatic factors and surgical therapy. Case Report A 12-year-old female patient complained a gingival swelling in region 2.1, following an orthodontic therapy. Following a careful evaluation of data collected by anamnesis and clinical and radiograph exams, the surgical excision of the lesion was scheduled. PGCG was confirmed by histological analysis. Finally, a series of follow up at one-, two-, three-, and eight-year were scheduled. Conclusion The long-term follow-ups seem to demonstrate that the surgical removal of a PGCG associated with bone resorption and deep periodontal pockets caused by development of the lesion may lead to the regeneration of new periodontal attachment for both the infrabony and the suprabony component of the periodontal pocket.