Cytokines have critical functions in regulating immune responses. A large number of these factors bind related receptors termed the Type I and Type II families of cytokine receptors. These receptors activate Janus kinases (Jaks) and Stat family of transcription factors. The essential and specific function of Jaks and Stats is particularly well illustrated by human and mouse mutations. The possibility that these molecules could be targeted to produce novel immunosuppressive compounds is considered in this review.
Jaks and Stats as therapeutic targets / O'Shea, J. J.; Visconti, R.; Cheng, T. P.; Gadina, M.. - In: ANNALS OF THE RHEUMATIC DISEASES. - ISSN 0003-4967. - 59:1(2000), pp. 115-118. [10.1136/ard.59.suppl_1.i115]
Jaks and Stats as therapeutic targets
Visconti R.;
2000
Abstract
Cytokines have critical functions in regulating immune responses. A large number of these factors bind related receptors termed the Type I and Type II families of cytokine receptors. These receptors activate Janus kinases (Jaks) and Stat family of transcription factors. The essential and specific function of Jaks and Stats is particularly well illustrated by human and mouse mutations. The possibility that these molecules could be targeted to produce novel immunosuppressive compounds is considered in this review.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
