The chemical synthesis of two new G-rich Tetra-End-Linked-oligodeoxyribonucleotides (TEL-ODNs) as well as (1)H-NMR and CD spectra of the corresponding monomolecular quadruplexes (IVa and IVb) has been reported. The new TEL-ODNs, characterized by the presence of short branches in the linker moiety, could be very useful for the achievement of monomolecular quadruplexes with predetermined strand orientation.

Synthesis and characterization of tetra-end linked oligonucleotides capable of forming monomolecular G-quadruplex

BORBONE, NICOLA;OLIVIERO, GIORGIA;AMATO, JUSSARA;D'ERRICO, STEFANO;GALEONE, ALDO;PICCIALLI, GENNARO;MAYOL, LUCIANO
2007

Abstract

The chemical synthesis of two new G-rich Tetra-End-Linked-oligodeoxyribonucleotides (TEL-ODNs) as well as (1)H-NMR and CD spectra of the corresponding monomolecular quadruplexes (IVa and IVb) has been reported. The new TEL-ODNs, characterized by the presence of short branches in the linker moiety, could be very useful for the achievement of monomolecular quadruplexes with predetermined strand orientation.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/100372
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