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Predisposing factor, impactful adjunctive treatment or unfavorable prognostic marker: a meta-analysis on the elusive role of dexamethasone for Listeria monocytogenes meningitis.

The revival of aztreonam in combination with avibactam against metallo-β-lactamase-producing gram-negatives: A systematic review of in vitro studies and clinical cases

Infections caused by metallo-β-lactamase (MBL)-producing Enterobacterales and Pseudo-monas are increasingly reported worldwide and are usually associated with high mortality rates (>30%). Neither standard therapy nor consensus for the management of these infections exist. Aztreonam, an old β-lactam antibiotic, is not hydrolyzed by MBLs. However, since many MBL-producing strains co-produce enzymes that could hydrolyze aztreonam (e.g., AmpC, ESBL), a robust β-lactamase inhibitor such as avibact...

The Use of Tocilizumab in Patients with COVID-19: A Systematic Review, Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Studies

Background: Among the several therapeutic options assessed for the treatment of coronavirus disease 2019 (COVID-19), tocilizumab (TCZ), an antagonist of the interleukine-6 receptor, has emerged as a promising therapeutic choice, especially for the severe form of the disease. Proper synthesis of the available randomized clinical trials (RCTs) is needed to inform clinical practice. Methods: A systematic review with a meta-analysis of RCTs investigating the efficacy of TCZ in COVID-19 patients w...

Clinical and nutritional correlates associated with weight changes in achalasia patients and the impact of laparoscopic Heller myotomy

Background: Achalasia is characterized by symptoms of esophageal obstruction, preventing food consumption. However, weight loss is observed only in a subset of patients, and data from literature is conflicting. Aims: Our study aimed at evaluating predictors of weight loss in achalasia patients and at verifying the impact of treatment on nutritional status. Methods: 123 achalasia patients, eligible for laparoscopic Heller myotomy, were studied. Demographic, clinical and nutritional data (calor...

Among- and within-population variation in germination response shapes ecological resilience in the Mediterranean cliff species Brassica incana Ten

Background and aims: Understanding how plant species respond to extreme conditions is crucial for predicting their ecological resilience under climate change. Here, we aim to forecast the ecological resilience of the Mediterranean cliff species Brassica incana (Brassicaceae) by estimating population variation in germination response under novel extreme environmental conditions. Methods: We investigated the thermal germination responses in 14 populations of B. incana by exposing seeds to tempe...

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NEUROTOXICITY INDUCED BY ALCL3 IN ZEBRAFISH BRAIN
Pensiero caring ed educazione affettiva nel progetto della Philosophy for Children
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Prodotti recenti

Predisposing factor, impactful adjunctive treatment or unfavorable prognostic marker: a meta-analysis on the elusive role of dexamethasone for Listeria monocytogenes meningitis.

The revival of aztreonam in combination with avibactam against metallo-β-lactamase-producing gram-negatives: A systematic review of in vitro studies and clinical cases

The Use of Tocilizumab in Patients with COVID-19: A Systematic Review, Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Studies

Clinical and nutritional correlates associated with weight changes in achalasia patients and the impact of laparoscopic Heller myotomy

Among- and within-population variation in germination response shapes ecological resilience in the Mediterranean cliff species Brassica incana Ten

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