Oxidative stress plays an important role in both initiation and progression of neurodegenerative diseases, such as Alzheimer and Parkinson. Therefore, much attention has been paid to antioxidants for developing therapeutic strategies for the neurodegenerative diseases. However, as serious adverse effects are related to synthetic antioxidants, recent research has been focused on natural products especially phenolic antioxidants. In the present article, we critically review the available literature related to the beneficial role of ferulic acid on Alzheimer's disease, since it is a natural antioxidant which is widely found in different fruits and vegetables. We also provide some informations about sources, chemical structure, bioavailability and clinical impacts of ferulic acid.

Ferulic acid and Alzheimer's disease: promises and pitfalls / Nabavi Seyed, Fazel; Devi Kasi, Pandima; Malar Dicson, Sheeja; Sureda, Antoni; Daglia, Maria; Nabavi Seyed, Mohammad. - In: MINI-REVIEWS IN MEDICINAL CHEMISTRY. - ISSN 1875-5607. - 15:9(2015), pp. 776-788. [10.2174/1389557515666150522102545]

Ferulic acid and Alzheimer's disease: promises and pitfalls

Daglia Maria;
2015

Abstract

Oxidative stress plays an important role in both initiation and progression of neurodegenerative diseases, such as Alzheimer and Parkinson. Therefore, much attention has been paid to antioxidants for developing therapeutic strategies for the neurodegenerative diseases. However, as serious adverse effects are related to synthetic antioxidants, recent research has been focused on natural products especially phenolic antioxidants. In the present article, we critically review the available literature related to the beneficial role of ferulic acid on Alzheimer's disease, since it is a natural antioxidant which is widely found in different fruits and vegetables. We also provide some informations about sources, chemical structure, bioavailability and clinical impacts of ferulic acid.
2015
Ferulic acid and Alzheimer's disease: promises and pitfalls / Nabavi Seyed, Fazel; Devi Kasi, Pandima; Malar Dicson, Sheeja; Sureda, Antoni; Daglia, Maria; Nabavi Seyed, Mohammad. - In: MINI-REVIEWS IN MEDICINAL CHEMISTRY. - ISSN 1875-5607. - 15:9(2015), pp. 776-788. [10.2174/1389557515666150522102545]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/766936
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