Nutrient availability is critical for the physiological functions of all tissues. By contrast, an excess of nutrients such as carbohydrate and fats impair health and shorten life due by stimulating chronic diseases, including diabetes, cancer and neurodegeneration. The control of circulating glucose and lipid levels involve mitochondria in both central and peripheral mechanisms of metabolism regulation. Mitochondrial uncoupling protein 2 (UCP2) has been implicated in physiological and pathological processes related to glucose and lipid metabolism, and in this review we discuss the latest data on the relationships between UCP2 and glucose and lipid sensing from the perspective of specific hypothalamic neuronal circuits and peripheral tissue functions. The goal is to provide a framework for discussion of future therapeutic strategies for metabolism-related chronic diseases.

Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism / Diano, Sabrina; Horvath, Tamas L. - In: TRENDS IN MOLECULAR MEDICINE. - ISSN 1471-4914. - 18:1(2012), pp. 52-58. [10.1016/j.molmed.2011.08.003]

Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism

Diano, Sabrina;
2012

Abstract

Nutrient availability is critical for the physiological functions of all tissues. By contrast, an excess of nutrients such as carbohydrate and fats impair health and shorten life due by stimulating chronic diseases, including diabetes, cancer and neurodegeneration. The control of circulating glucose and lipid levels involve mitochondria in both central and peripheral mechanisms of metabolism regulation. Mitochondrial uncoupling protein 2 (UCP2) has been implicated in physiological and pathological processes related to glucose and lipid metabolism, and in this review we discuss the latest data on the relationships between UCP2 and glucose and lipid sensing from the perspective of specific hypothalamic neuronal circuits and peripheral tissue functions. The goal is to provide a framework for discussion of future therapeutic strategies for metabolism-related chronic diseases.
2012
Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism / Diano, Sabrina; Horvath, Tamas L. - In: TRENDS IN MOLECULAR MEDICINE. - ISSN 1471-4914. - 18:1(2012), pp. 52-58. [10.1016/j.molmed.2011.08.003]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/753398
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