Lysosomes are emerging as calcium store organelles that can modulate various intracellular processes such as the regulation of nutrient signaling through the activation of TFEB, a master gene for lysosomal function, or very specialized functions like lysosomal exocytosis. Here, we describe two different techniques that can be used to study these processes. In the case report, we described two studies where these methodologies allowed us to unravel the role of calcineurin in the dephosphorylation of TFEB as well as the involvement of TFEB in lysosomal exocytosis, respectively.

Ca2+-dependent regulation of TFEB and lysosomal function / Di Paola, Simone; Medina, Dl. - 1925:(2019), pp. 145-155. [10.1007/978-1-4939-9018-4_13]

Ca2+-dependent regulation of TFEB and lysosomal function

Medina, DL
2019

Abstract

Lysosomes are emerging as calcium store organelles that can modulate various intracellular processes such as the regulation of nutrient signaling through the activation of TFEB, a master gene for lysosomal function, or very specialized functions like lysosomal exocytosis. Here, we describe two different techniques that can be used to study these processes. In the case report, we described two studies where these methodologies allowed us to unravel the role of calcineurin in the dephosphorylation of TFEB as well as the involvement of TFEB in lysosomal exocytosis, respectively.
2019
978-1-4939-9018-4
Ca2+-dependent regulation of TFEB and lysosomal function / Di Paola, Simone; Medina, Dl. - 1925:(2019), pp. 145-155. [10.1007/978-1-4939-9018-4_13]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/752946
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