Emerging experimental evidences indicate that the lysosome can trigger a calcium signaling, via TRPML1/calcineurin/TFEB pathway, that promotes lysosomal exocytosis and clearance of lysosomal accumulation in various cellular models of lysosomal storage disorders (LSDs). Here, we described methods to determine TFEB activation and lysosomal exocytosis that may represent innovative tools to study lysosomal function and to develop novel therapeutic approaches to promote clearance in LSDs

TRPML1-/TFEB-dependent regulation of lysosomal exocytosis / Di Paola, Simone; Medina, Dl. - 1925:(2019), pp. 143-144. [10.1007/978-1-4939-9018-4_12]

TRPML1-/TFEB-dependent regulation of lysosomal exocytosis

Medina, DL
2019

Abstract

Emerging experimental evidences indicate that the lysosome can trigger a calcium signaling, via TRPML1/calcineurin/TFEB pathway, that promotes lysosomal exocytosis and clearance of lysosomal accumulation in various cellular models of lysosomal storage disorders (LSDs). Here, we described methods to determine TFEB activation and lysosomal exocytosis that may represent innovative tools to study lysosomal function and to develop novel therapeutic approaches to promote clearance in LSDs
2019
978-1-4939-9018-4
TRPML1-/TFEB-dependent regulation of lysosomal exocytosis / Di Paola, Simone; Medina, Dl. - 1925:(2019), pp. 143-144. [10.1007/978-1-4939-9018-4_12]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/752945
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