Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by inflammation of the synovial membrane, with thickening of the synovial layer, cellular hyperplasia, and infiltration of immune cells. Mast cells (MCs) are cells of the innate immunity present in healthy synovia and part of the cellular hyperplasia characterizing RA synovitis. Although their presence in synovia has been well described, the exact functions and the correlation of MCs with disease development and progression have been debated, particularly because of contradictory data obtained in animal models and from patients with longstanding disease. Here, we present a revision of the literature on MCs in RA, including the most recent observations obtained from patients with early RA, indicating MCs as relevant markers of disease severity in early RA.

Mast Cells in Early Rheumatoid Arthritis / Rivellese, F; Rossi, Fw; Galdiero, Mr; Pitzalis, Marco; de Paulis, A.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 20:8(2019), p. 2040. [10.3390/ijms20082040]

Mast Cells in Early Rheumatoid Arthritis

Rossi FW;Galdiero MR;PITZALIS, MARCO;de Paulis A.
2019

Abstract

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by inflammation of the synovial membrane, with thickening of the synovial layer, cellular hyperplasia, and infiltration of immune cells. Mast cells (MCs) are cells of the innate immunity present in healthy synovia and part of the cellular hyperplasia characterizing RA synovitis. Although their presence in synovia has been well described, the exact functions and the correlation of MCs with disease development and progression have been debated, particularly because of contradictory data obtained in animal models and from patients with longstanding disease. Here, we present a revision of the literature on MCs in RA, including the most recent observations obtained from patients with early RA, indicating MCs as relevant markers of disease severity in early RA.
2019
Mast Cells in Early Rheumatoid Arthritis / Rivellese, F; Rossi, Fw; Galdiero, Mr; Pitzalis, Marco; de Paulis, A.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 20:8(2019), p. 2040. [10.3390/ijms20082040]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/751595
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