Outcome of bovine tuberculosis (bTB), an infectious disease caused by Mycobacterium bovis, is influenced by host genetic background. For this reason, polymorphism discovery association studies are a powerful tool for selective breeding helping disease control. Interleukin-10 (IL-10) is a regulatory cytokine produced by different cells and fine-tune immune response to bTB. Thus, in this research, we evaluated the role of the single nucleotide polymorphism g.4002C>T in IL-10 gene for susceptibility to bTB in Mediterranean water buffalo. We characterized 184 animals grouped in cases and controls and demonstrated that homozygous subjects TT are about 3 times more susceptible to bTB compared to CC homozygous. Indeed this polymorphism is responsible of amino acid substitution p. (Thr 175 Met) in the primary protein sequence which affects protein secondary structure. This polymorphism might represent a valid tool for marker assisted selection against bovine tuberculosis in water buffalo.
Water buffalo (Bubalus bubalis) susceptibility to bovine tuberculosis is influenced by g.4002C>T polymorphism in interleukin-10 gene / Iannaccone, M.; Cosenza, G.; Pauciullo, A.; Martino, C.; Ianni, A.; Capparelli, R.; Martino, G.. - In: BUFFALO BULLETIN. - ISSN 0125-6726. - 38:1(2019), pp. 135-139. (Intervento presentato al convegno ASPA 23nd Congress of the Animal Science and Production Association tenutosi a Sorrento (Italy) nel June 11–14, 2019) [10.1080/1828051X.2019.1622269].
Water buffalo (Bubalus bubalis) susceptibility to bovine tuberculosis is influenced by g.4002C>T polymorphism in interleukin-10 gene
IANNACCONE M.
;COSENZA G.;CAPPARELLI R.;
2019
Abstract
Outcome of bovine tuberculosis (bTB), an infectious disease caused by Mycobacterium bovis, is influenced by host genetic background. For this reason, polymorphism discovery association studies are a powerful tool for selective breeding helping disease control. Interleukin-10 (IL-10) is a regulatory cytokine produced by different cells and fine-tune immune response to bTB. Thus, in this research, we evaluated the role of the single nucleotide polymorphism g.4002C>T in IL-10 gene for susceptibility to bTB in Mediterranean water buffalo. We characterized 184 animals grouped in cases and controls and demonstrated that homozygous subjects TT are about 3 times more susceptible to bTB compared to CC homozygous. Indeed this polymorphism is responsible of amino acid substitution p. (Thr 175 Met) in the primary protein sequence which affects protein secondary structure. This polymorphism might represent a valid tool for marker assisted selection against bovine tuberculosis in water buffalo.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
