Studies of alterations in histone methylation in cancer have led to the identification of histone methyltransferases and demethylases as novel targets for therapy. Lysine-specific demethylase 1 (LSD1, also known as KDM1A), demethylates H3K4me1/2, or H3K9me1/2 in a context-dependent manner. In addition to the well-studied role of LSD1 in the epigenetic regulation of histone methylation changes, LSD1 regulates the methylation dynamic of several non-histone proteins and participates in the assembly of different long noncoding RNA (lncRNA_ complexes. LSD1 is highly expressed in various cancers, playing a pivotal role in different cancer-related processes. Here, we summarized recent findings on the role of LSD1 in the regulation of different biological processes in cancer cells through dynamic methylation of non-histone proteins and physical association with dedicated lncRNA.

Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer / Majello, Barbara; Gorini, Francesca; Saccà, Carmen Daniela; Amente, Stefano. - In: CANCERS. - ISSN 2072-6694. - 11:3(2019), p. 324. [10.3390/cancers11030324]

Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer

Majello, Barbara
Writing – Original Draft Preparation
;
Gorini, Francesca
Writing – Original Draft Preparation
;
Saccà, Carmen Daniela
Writing – Original Draft Preparation
;
Amente, Stefano
Writing – Original Draft Preparation
2019

Abstract

Studies of alterations in histone methylation in cancer have led to the identification of histone methyltransferases and demethylases as novel targets for therapy. Lysine-specific demethylase 1 (LSD1, also known as KDM1A), demethylates H3K4me1/2, or H3K9me1/2 in a context-dependent manner. In addition to the well-studied role of LSD1 in the epigenetic regulation of histone methylation changes, LSD1 regulates the methylation dynamic of several non-histone proteins and participates in the assembly of different long noncoding RNA (lncRNA_ complexes. LSD1 is highly expressed in various cancers, playing a pivotal role in different cancer-related processes. Here, we summarized recent findings on the role of LSD1 in the regulation of different biological processes in cancer cells through dynamic methylation of non-histone proteins and physical association with dedicated lncRNA.
2019
Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer / Majello, Barbara; Gorini, Francesca; Saccà, Carmen Daniela; Amente, Stefano. - In: CANCERS. - ISSN 2072-6694. - 11:3(2019), p. 324. [10.3390/cancers11030324]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/747231
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