Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food. Some gliadin peptides are not digested by intestinal proteases and can have different biological effects. Gliadin peptides can induce innate and adaptive T cell-mediated immune responses. The major mediator of the stress and innate immune response to gliadin peptides (i.e., peptides 31-43 and 31-55) is the cytokine interleukin-15 (IL-15). Other peptides such as the 33 mer containing the P57-68 sequence, after tissue transglutaminase deamidation, are well presented to T cell in the intestine and can induce an adaptive immune response.

Endocytosis and transcytosis of gliadin peptides / Barone, M Vittoria; Zimmer, K Peter. - In: MOLECULAR AND CELLULAR PEDIATRICS. - ISSN 2194-7791. - 3:1(2016), p. 8. [10.1186/s40348-015-0029-z]

Endocytosis and transcytosis of gliadin peptides

Barone, M Vittoria;
2016

Abstract

Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food. Some gliadin peptides are not digested by intestinal proteases and can have different biological effects. Gliadin peptides can induce innate and adaptive T cell-mediated immune responses. The major mediator of the stress and innate immune response to gliadin peptides (i.e., peptides 31-43 and 31-55) is the cytokine interleukin-15 (IL-15). Other peptides such as the 33 mer containing the P57-68 sequence, after tissue transglutaminase deamidation, are well presented to T cell in the intestine and can induce an adaptive immune response.
2016
Endocytosis and transcytosis of gliadin peptides / Barone, M Vittoria; Zimmer, K Peter. - In: MOLECULAR AND CELLULAR PEDIATRICS. - ISSN 2194-7791. - 3:1(2016), p. 8. [10.1186/s40348-015-0029-z]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/742740
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