Cutaneous melanoma (CM) is the most lethal skin malignancy, with a constant increase in incidence. These tumors show a biological behavior unpredictable by the classical parameters Moreover, conventional therapies are ineffective to treat advanced stage case. Therefore, the identification of molecular alterations involved in their biological aggressiveness represents a major challenge for researchers. Accumulating evidence supports the involvement of cancer stem cells (CSC) in initiation, progression, chemoresistance and therapeutic failure of malignant melanoma, and the aggressive subsets of melanoma cells have been frequently associated with molecular markers shared by stem cells.
Detection of Biological Profile of Cutaneous Malignant Melanoma: A Role For Caf-1/p60 Protein and Stem-cell Marker Cd133 Expression? / Staibano, Stefania; Mascolo, Massimo; M., Di Benedetto; Ilardi, Gennaro; M. L., Vecchione; G., Salvatore; L., Nugnes; DE ROSA, Gaetano. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - 28:5C(2008), pp. 3497-3498. (Intervento presentato al convegno Eighth International Conference of Anticancer Research tenutosi a Kos, Grecia nel 17-22 ottobre 2008).
Detection of Biological Profile of Cutaneous Malignant Melanoma: A Role For Caf-1/p60 Protein and Stem-cell Marker Cd133 Expression?
STAIBANO, STEFANIA;MASCOLO, MASSIMO;ILARDI, GENNARO;DE ROSA, GAETANO
2008
Abstract
Cutaneous melanoma (CM) is the most lethal skin malignancy, with a constant increase in incidence. These tumors show a biological behavior unpredictable by the classical parameters Moreover, conventional therapies are ineffective to treat advanced stage case. Therefore, the identification of molecular alterations involved in their biological aggressiveness represents a major challenge for researchers. Accumulating evidence supports the involvement of cancer stem cells (CSC) in initiation, progression, chemoresistance and therapeutic failure of malignant melanoma, and the aggressive subsets of melanoma cells have been frequently associated with molecular markers shared by stem cells.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
