Orexin system regulates sleep/wake states and its deficiency result in narcolepsy thus indicating the crucial role of orexins in maintaining wakefulness. There are two types of orexin peptides: the orexin-A (OXA or hypocretin 1) and orexin-B (OXB or hypocre- tin 2). The Majority of the central nervous system orexin peptides are synthesized in neurons located in the lateral and back hypotha- lamus and send projections throughout the brain regions Orexin neurons are “multi-tasking” hence regulating also energy homeosta- sis, reward systems and feeding behaviour through connection with hypothalamic nuclei and through responsiveness to leptine and glucose. It has recently been found a connection with lymbic system suggesting a further possible role of orexins in regulating emo- tions. All the studies conducted confirm that orexin system regulates vigilance states, energy homeostasis, reward system, and emo- tions. These crucial role might be the target to develope treatments of narcolepsy, obesity, emotional stress, and drug addiction.
Orexin system: Network multi-tasking / Sperandeo, Raffaele; Maldonato, Mauro N.; Messina, Antonietta; Cozzolino, Pasquale; Monda, Marcellino; Cerroni, Francesco; Romano, Palmira; Salerno, Margherita; Maltese, Agata; Roccella, Michele; Parisi, Lucia; Tripi, Gabriele; Moscatelli, Fiorenzo; Sessa, Francesco; Salerno, Monica; Cibelli, Giuseppe; Messina, Giovanni; Monda, Vincenzo; Chieffi, Sergio; Villano, Ines; Monda, Emanuele; Ruberto, Maria; Marsala, Gabriella; Marotta, Rosa; Valenzano, Anna. - In: ACTA MEDICA MEDITERRANEA. - ISSN 0393-6384. - 34:2(2018), pp. 349-356. [10.19193/0393-6384_2018_2_55]
Orexin system: Network multi-tasking
Maldonato, Mauro N.;
2018
Abstract
Orexin system regulates sleep/wake states and its deficiency result in narcolepsy thus indicating the crucial role of orexins in maintaining wakefulness. There are two types of orexin peptides: the orexin-A (OXA or hypocretin 1) and orexin-B (OXB or hypocre- tin 2). The Majority of the central nervous system orexin peptides are synthesized in neurons located in the lateral and back hypotha- lamus and send projections throughout the brain regions Orexin neurons are “multi-tasking” hence regulating also energy homeosta- sis, reward systems and feeding behaviour through connection with hypothalamic nuclei and through responsiveness to leptine and glucose. It has recently been found a connection with lymbic system suggesting a further possible role of orexins in regulating emo- tions. All the studies conducted confirm that orexin system regulates vigilance states, energy homeostasis, reward system, and emo- tions. These crucial role might be the target to develope treatments of narcolepsy, obesity, emotional stress, and drug addiction.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.