Synthesis and Crystal Structure of 3-{4-[(4-(2-Oxo-2,3-dihydro-1H-benzilimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole

The X-ray crystal structure of 3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole, a compound that showed high cytotoxic potential against various leukemia cell lines, was established. The 3D spatial determination confirmed the structure in the solid state. It crystallizes inthe triclinic space group P-1 with cell parameters a=9.572(7) Å, b=11.091(2) Å, c=15.976(4) Å, α=92.53(2), β=105.45(3), γ=94.65(3), V=1625.6(13) Å3 and Z=2. The crystal structure was refined to final values of R1=0.0638 and wR2=0.1800. The crystal packing is controlled by intermolecular hydrogen bonding and C-H interactions. In addition, these new data could be further used to clarify the mechanism of action, implicating the antiproliferative effect of this new synthetic indole derivative on human leukemic cells.