From the whole plant of Euphorbia cyparissias, two new diterpenes based on jatrophane skeleton, named cyparissins A and B (1 and 2) were isolated. Their chem. structures were established through a combination of NMR spectroscopy and mass spectrometric methods. The new cyparissins A and B were tested to evaluate their ability to inhibit P-glycoprotein-mediated multidrug resistance and their cytotoxic activity against A2780 human ovarian cancer cells, both WT and ADR. Compds. 1 and 2 showed moderate inhibitory effects on P-glycoprotein while showing a significant concn.-depending cytotoxic activity for both cancer cell lines. These isolated compds. are based on a new chem. structure that expands the knowledge base for this class of bioactive metabolites. [on SciFinder(R)]
Cyparissins A and B, jatrophane diterpenes from Euphorbia cyparissias as Pgp inhibitors and cytotoxic agents against ovarian cancer cell lines / Lanzotti, Virginia; Barile, Elisa; Scambia, Giovanni; Ferlini, C. r. i. s. t. i. a. n. o.. - In: FITOTERAPIA. - ISSN 1971-551X. - 104:(2015), pp. 75-79. [10.1016/j.fitote.2015.05.012]
Cyparissins A and B, jatrophane diterpenes from Euphorbia cyparissias as Pgp inhibitors and cytotoxic agents against ovarian cancer cell lines
LANZOTTI, VIRGINIA;
2015
Abstract
From the whole plant of Euphorbia cyparissias, two new diterpenes based on jatrophane skeleton, named cyparissins A and B (1 and 2) were isolated. Their chem. structures were established through a combination of NMR spectroscopy and mass spectrometric methods. The new cyparissins A and B were tested to evaluate their ability to inhibit P-glycoprotein-mediated multidrug resistance and their cytotoxic activity against A2780 human ovarian cancer cells, both WT and ADR. Compds. 1 and 2 showed moderate inhibitory effects on P-glycoprotein while showing a significant concn.-depending cytotoxic activity for both cancer cell lines. These isolated compds. are based on a new chem. structure that expands the knowledge base for this class of bioactive metabolites. [on SciFinder(R)]I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.