Beta2-adrenergic receptor Thr164Ile (threonine (Thr) is replaced by an isoleucine (Ile) at codon 164) polymorphism was postulated to contribute to lower exercise tolerance and poor prognosis in patients with congestive heart failure. However, heart failure is associated with several abnormalities of beta receptor signalling, and underlying mechanisms are not clear.
Thr164Ile polymorphism of beta2-adrenergic receptor negatively modulates cardiac contractility: implications for prognosis in patients with idiopathic dilated cardiomyopathy / Barbato, Emanuele; Penicka, Martin; Delrue, Leen; Van Durme, Frederic; De Bruyne, Bernard; Goethals, Marc; Wijns, William; Vanderheyden, Marc; Bartunek, Jozef. - In: HEART. - ISSN 1468-201X. - 93:7(2007), pp. 856-861. [10.1136/hrt.2006.091959]
Thr164Ile polymorphism of beta2-adrenergic receptor negatively modulates cardiac contractility: implications for prognosis in patients with idiopathic dilated cardiomyopathy
BARBATO, EMANUELE;
2007
Abstract
Beta2-adrenergic receptor Thr164Ile (threonine (Thr) is replaced by an isoleucine (Ile) at codon 164) polymorphism was postulated to contribute to lower exercise tolerance and poor prognosis in patients with congestive heart failure. However, heart failure is associated with several abnormalities of beta receptor signalling, and underlying mechanisms are not clear.| File | Dimensione | Formato | |
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