The X-ray structure of the adduct formed in the reaction between the gold N-heterocyclic carbene compound Au(NHC)Cl (with NHC = 1-butyl-3-methyl-imidazole-2-ylidene) and the model protein thaumatin is reported here. The structure reveals binding of Au(NHC)(+) fragments to distinct protein sites. Notably, binding of the gold compound occurs at lysine side chains and at the N-terminal tail; the metal binds the protein after releasing Cl(-) ligand, but retaining NHC fragment
First Crystal Structure for a Gold Carbene-Protein Adduct / Ferraro, Giarita; Gabbiani, Chiara; Merlino, Antonello. - In: BIOCONJUGATE CHEMISTRY. - ISSN 1043-1802. - 27:7(2016), pp. 1584-1587. [10.1021/acs.bioconjchem.6b00298]
First Crystal Structure for a Gold Carbene-Protein Adduct
FERRARO, GIARITA;MERLINO, ANTONELLO
2016
Abstract
The X-ray structure of the adduct formed in the reaction between the gold N-heterocyclic carbene compound Au(NHC)Cl (with NHC = 1-butyl-3-methyl-imidazole-2-ylidene) and the model protein thaumatin is reported here. The structure reveals binding of Au(NHC)(+) fragments to distinct protein sites. Notably, binding of the gold compound occurs at lysine side chains and at the N-terminal tail; the metal binds the protein after releasing Cl(-) ligand, but retaining NHC fragmentI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
