CCDC6 gene product is a tumor-suppressor pro-apoptotic protein, substrate of ATM, involved in DNA damage response and repair. Altered levels of CCDC6 expression are dependent on post-translational modifications, being the de-ubiquitinating enzyme USP7 responsible of the fine tuning of the CCDC6 stability. Thus, our aim was to investigate CCDC6 and USP7 expression levels in Lung-Neuroendocrine Tumors (L-NETs) to verify if they correlate and may be exploited as novel predictive therapeutic markers.
USP7 inhibitors, downregulating CCDC6, sensitize lung neuroendocrine cancer cells to PARP-inhibitor drugs / Malapelle, Umberto; Morra, Francesco; Ilardi, Gennaro; Visconti, Roberta; Merolla, Francesco; Cerrato, Aniello; Napolitano, Virginia; Monaco, Roberto; Guggino, Gianluca; Monaco, Guglielmo; Staibano, Stefania; Troncone, Giancarlo; Celetti, Angela. - In: LUNG CANCER. - ISSN 0169-5002. - 107:(2017), pp. 41-49. [10.1016/j.lungcan.2016.06.015]
USP7 inhibitors, downregulating CCDC6, sensitize lung neuroendocrine cancer cells to PARP-inhibitor drugs
MALAPELLE, UMBERTO;MORRA, FRANCESCO;ILARDI, GENNARO;VISCONTI, ROBERTA;MEROLLA, FRANCESCO;CERRATO, ANIELLO;NAPOLITANO, VIRGINIA;STAIBANO, STEFANIA;TRONCONE, GIANCARLO;CELETTI, ANGELA
2017
Abstract
CCDC6 gene product is a tumor-suppressor pro-apoptotic protein, substrate of ATM, involved in DNA damage response and repair. Altered levels of CCDC6 expression are dependent on post-translational modifications, being the de-ubiquitinating enzyme USP7 responsible of the fine tuning of the CCDC6 stability. Thus, our aim was to investigate CCDC6 and USP7 expression levels in Lung-Neuroendocrine Tumors (L-NETs) to verify if they correlate and may be exploited as novel predictive therapeutic markers.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
