The natural sequences of nucleic acids generally consist of nucleotides linked together by canonical 3'-5' phosphodiester bonds. An inversion of polarity site (IPS) can be defined as the point of the sequence in which a 3'-3' or a 5'-5' phosphodiester bond occurs. By extending this definition, an IPS can be described as that part of the sequence in which two 3'- or two 5'-hydroxyl groups are connected by a linker, variable in size or in chemical nature. In G-quadruplex structures an IPS can be introduced in three different positions: inside a non G-tract, inside a G-tract and just between a non Gtract and a G-tract. Investigations have been reported concerning all the three types of modification. This review describes the effects of the presence of one or more IPSs in G-quadruplex structures, particularly regarding their topological and structural characteristics, glycosidic bond preference, and thermal stability, with special attention to biologically active Gquadruplex forming aptamers. The perspectives and potential developments of this research area are also discussed.

The Introduction of Inversion of Polarity Sites in DNA G-Quadruplex Structures: Effects and Perspectives / Virgilio, Antonella; Esposito, Veronica; Filosa, Rosanna; Mayol, Luciano; Galeone, Aldo. - In: MINI-REVIEWS IN MEDICINAL CHEMISTRY. - ISSN 1389-5575. - 16:7(2016), pp. 509-523. [10.2174/1389557515666150909143215]

The Introduction of Inversion of Polarity Sites in DNA G-Quadruplex Structures: Effects and Perspectives

VIRGILIO, ANTONELLA
Primo
;
ESPOSITO, VERONICA
Secondo
;
MAYOL, LUCIANO
Penultimo
;
GALEONE, ALDO
Ultimo
2016

Abstract

The natural sequences of nucleic acids generally consist of nucleotides linked together by canonical 3'-5' phosphodiester bonds. An inversion of polarity site (IPS) can be defined as the point of the sequence in which a 3'-3' or a 5'-5' phosphodiester bond occurs. By extending this definition, an IPS can be described as that part of the sequence in which two 3'- or two 5'-hydroxyl groups are connected by a linker, variable in size or in chemical nature. In G-quadruplex structures an IPS can be introduced in three different positions: inside a non G-tract, inside a G-tract and just between a non Gtract and a G-tract. Investigations have been reported concerning all the three types of modification. This review describes the effects of the presence of one or more IPSs in G-quadruplex structures, particularly regarding their topological and structural characteristics, glycosidic bond preference, and thermal stability, with special attention to biologically active Gquadruplex forming aptamers. The perspectives and potential developments of this research area are also discussed.
2016
The Introduction of Inversion of Polarity Sites in DNA G-Quadruplex Structures: Effects and Perspectives / Virgilio, Antonella; Esposito, Veronica; Filosa, Rosanna; Mayol, Luciano; Galeone, Aldo. - In: MINI-REVIEWS IN MEDICINAL CHEMISTRY. - ISSN 1389-5575. - 16:7(2016), pp. 509-523. [10.2174/1389557515666150909143215]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/635200
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