Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against malignant transformation. Accordingly, many oncoproteins inhibit, and several oncosuppressor proteins promote, autophagy. Moreover, autophagy is required for optimal anticancer immunosurveillance. In neoplastic cells, however, autophagic responses constitute a means to cope with intracellular and environmental stress, thus favoring tumor progression. This implies that at least in some cases, oncogenesis proceeds along with a temporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive activity. Here, we discuss the differential impact of autophagy on distinct phases of tumorigenesis and the implications of this concept for the use of autophagy modulators in cancer therapy.

Autophagy in malignant transformation and cancer progression / Galluzzi, Lorenzo; Pietrocola, Federico; Bravo San Pedro, José Manuel; Amaravadi, Ravi K.; Baehrecke, Eric H.; Cecconi, Francesco; Codogno, Patrice; Debnath, Jayanta; Gewirtz, David A.; Karantza, Vassiliki; Kimmelman, Alec; Kumar, Sharad; Levine, Beth; Maiuri, MARIA CHIARA; Martin, Seamus J.; Penninger, Josef; Piacentini, Mauro; Rubinsztein, David C.; Simon, Hans Uwe; Simonsen, Anne; Thorburn, Andrew M.; Velasco, Guillermo; Ryan, Kevin M.; Kroemer, Guido. - In: EMBO JOURNAL. - ISSN 0261-4189. - 34:7(2015), pp. 856-880. [10.15252/embj.201490784]

Autophagy in malignant transformation and cancer progression

MAIURI, MARIA CHIARA;
2015

Abstract

Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against malignant transformation. Accordingly, many oncoproteins inhibit, and several oncosuppressor proteins promote, autophagy. Moreover, autophagy is required for optimal anticancer immunosurveillance. In neoplastic cells, however, autophagic responses constitute a means to cope with intracellular and environmental stress, thus favoring tumor progression. This implies that at least in some cases, oncogenesis proceeds along with a temporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive activity. Here, we discuss the differential impact of autophagy on distinct phases of tumorigenesis and the implications of this concept for the use of autophagy modulators in cancer therapy.
2015
Autophagy in malignant transformation and cancer progression / Galluzzi, Lorenzo; Pietrocola, Federico; Bravo San Pedro, José Manuel; Amaravadi, Ravi K.; Baehrecke, Eric H.; Cecconi, Francesco; Codogno, Patrice; Debnath, Jayanta; Gewirtz, David A.; Karantza, Vassiliki; Kimmelman, Alec; Kumar, Sharad; Levine, Beth; Maiuri, MARIA CHIARA; Martin, Seamus J.; Penninger, Josef; Piacentini, Mauro; Rubinsztein, David C.; Simon, Hans Uwe; Simonsen, Anne; Thorburn, Andrew M.; Velasco, Guillermo; Ryan, Kevin M.; Kroemer, Guido. - In: EMBO JOURNAL. - ISSN 0261-4189. - 34:7(2015), pp. 856-880. [10.15252/embj.201490784]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/621042
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 962
  • ???jsp.display-item.citation.isi??? 913
social impact