The relationship between serum uric acid (UA) and cardiovascular risk profile was investigated in 557 outpatients (415 women) aged 60 years and older. Patients were grouped according to a UA cutoff level of 5.5 mg/dL. Prevalence of obesity, hypertension, and impaired glucose metabolism was increased in women with higher UA, who had higher body mass index (37.76.9 vs 33.15.9 kg/m2, P<.001), waist circumference, and serum glucose and triglyceride concentrations than women with lower UA levels. Conversely, men with higher UA levels showed lower highdensity lipoprotein cholesterol and higher left ventricular mass than men with lower UA levels. Estimated glomerular filtration rate was reduced in patients with high UA levels of both sexes (6517 vs 7216 mL/min/1.73 m2, P<.001, for women; 7016 vs 7615 mL/min/1.73 m2, P<.03, for men). Grouping patients by sex-specific median UA concentrations produced similar results. These data indicate that, even in the elderly, UA clusters in a sex-specific fashion with features of metabolic syndrome and signs of target organ damage.
Association of hyperuricaemia with conventional cardiovascular risk factors in elderly patients / Marotta, Teodoro; Liccardo, Maria; Schettini, Federico; Verde, Francesco; Ferrara, LIBERATO ALDO. - In: THE JOURNAL OF CLINICAL HYPERTENSION. - ISSN 1524-6175. - 17:1(2015), pp. 27-32. [DOI: 10.1111/jch.12434]
Association of hyperuricaemia with conventional cardiovascular risk factors in elderly patients
VERDE, FRANCESCO;FERRARA, LIBERATO ALDO
2015
Abstract
The relationship between serum uric acid (UA) and cardiovascular risk profile was investigated in 557 outpatients (415 women) aged 60 years and older. Patients were grouped according to a UA cutoff level of 5.5 mg/dL. Prevalence of obesity, hypertension, and impaired glucose metabolism was increased in women with higher UA, who had higher body mass index (37.76.9 vs 33.15.9 kg/m2, P<.001), waist circumference, and serum glucose and triglyceride concentrations than women with lower UA levels. Conversely, men with higher UA levels showed lower highdensity lipoprotein cholesterol and higher left ventricular mass than men with lower UA levels. Estimated glomerular filtration rate was reduced in patients with high UA levels of both sexes (6517 vs 7216 mL/min/1.73 m2, P<.001, for women; 7016 vs 7615 mL/min/1.73 m2, P<.03, for men). Grouping patients by sex-specific median UA concentrations produced similar results. These data indicate that, even in the elderly, UA clusters in a sex-specific fashion with features of metabolic syndrome and signs of target organ damage.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.