Mitochondria are the main cellular sites devoted to ATP production and lipid oxidation. Therefore, the mitochondrial dysfunction could be an important determinant of cellular fate of circulating lipids, that accumulate in the cytoplasm, if they are not oxidized. The ectopic fat accumulation is associated with the development of insulin resistance, and a link between mitochondrial dysfunction and insulin resistance has been proposed.
A possible link between hepatic mitochondrial dysfunction and diet-induced insulin resistance / Crescenzo, Raffaella; Bianco, Francesca; Mazzoli, Arianna; Giacco, Antonia; Liverini, Giovanna; Iossa, Susanna. - In: EUROPEAN JOURNAL OF NUTRITION. - ISSN 1436-6207. - 55:(2016), pp. 1-6. [10.1007/s00394-015-1073-0]
A possible link between hepatic mitochondrial dysfunction and diet-induced insulin resistance
CRESCENZO, RAFFAELLA;BIANCO, FRANCESCA;MAZZOLI, ARIANNA;LIVERINI, GIOVANNA;IOSSA, SUSANNA
2016
Abstract
Mitochondria are the main cellular sites devoted to ATP production and lipid oxidation. Therefore, the mitochondrial dysfunction could be an important determinant of cellular fate of circulating lipids, that accumulate in the cytoplasm, if they are not oxidized. The ectopic fat accumulation is associated with the development of insulin resistance, and a link between mitochondrial dysfunction and insulin resistance has been proposed.| File | Dimensione | Formato | |
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