FK506 binding proteins (FKBP) are multifunctional proteins highly conserved across the species and abundantly expressed in the cell. In addition to a well-established role in immunosuppression, FKBPs modulate several signal transduction pathways in the cell, due to their isomerase activity and the capability to interact with other proteins, inducing changes in conformation and function of protein partners. Increasing literature data support the concept that FKBPs control cancer related pathways.
Pleiotropic roles in cancer biology for multifaceted proteins FKBPs / Romano, Simona; D'Angelillo, Anna; Romano, MARIA FIAMMETTA. - In: BIOCHIMICA ET BIOPHYSICA ACTA. - ISSN 0006-3002. - 1850:10(2015), pp. 2061-2068. [10.1016/j.bbagen.2015.01.004]
Pleiotropic roles in cancer biology for multifaceted proteins FKBPs
ROMANO, SIMONA;D'ANGELILLO, ANNA;ROMANO, MARIA FIAMMETTA
2015
Abstract
FK506 binding proteins (FKBP) are multifunctional proteins highly conserved across the species and abundantly expressed in the cell. In addition to a well-established role in immunosuppression, FKBPs modulate several signal transduction pathways in the cell, due to their isomerase activity and the capability to interact with other proteins, inducing changes in conformation and function of protein partners. Increasing literature data support the concept that FKBPs control cancer related pathways.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
