The structure of the capsular polysaccharide (CPS) from an Acinetobacter baumannii global clone 2 (GC2) clinical isolate RBH4 that carries the KL6 gene cluster was elucidated by means of chemical and spectroscopical methods. The repeating unit of K6 CPS is linear and contains N-acetyl-D-galactosamine (DGalpNAc), two D-galactose (D-Galp) residues and 5,7-di-N-acetylpseudaminic acid (Pse5Ac7Ac). The synthesis of these sugars could be attributed to genes in the KL6 capsule biosynthesis gene cluster, and the formation of the linkages between the sugars were assigned to glycosyltransferases or the Wzy polymerase encoded in KL6.
Structure of the K6 capsular polysaccharide from Acinetobacter baumannii isolate RBH4 / Johanna J., Kenyon; Marzaioli, ALBERTO MARIA; Ruth M., Hall; DE CASTRO, Cristina. - In: CARBOHYDRATE RESEARCH. - ISSN 0008-6215. - 409:(2015), pp. 30-35. [10.1016/j.carres.2015.03.016]
Structure of the K6 capsular polysaccharide from Acinetobacter baumannii isolate RBH4
MARZAIOLI, ALBERTO MARIA;DE CASTRO, CRISTINA
2015
Abstract
The structure of the capsular polysaccharide (CPS) from an Acinetobacter baumannii global clone 2 (GC2) clinical isolate RBH4 that carries the KL6 gene cluster was elucidated by means of chemical and spectroscopical methods. The repeating unit of K6 CPS is linear and contains N-acetyl-D-galactosamine (DGalpNAc), two D-galactose (D-Galp) residues and 5,7-di-N-acetylpseudaminic acid (Pse5Ac7Ac). The synthesis of these sugars could be attributed to genes in the KL6 capsule biosynthesis gene cluster, and the formation of the linkages between the sugars were assigned to glycosyltransferases or the Wzy polymerase encoded in KL6.| File | Dimensione | Formato | |
|---|---|---|---|
|
104_aciRBH4.pdf
solo utenti autorizzati
Tipologia:
Altro materiale allegato
Licenza:
Accesso privato/ristretto
Dimensione
1.69 MB
Formato
Adobe PDF
|
1.69 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
