Recent evidence has indicated that the lysosome is able to act as a signaling organelle that senses nutrient availability and generates an adaptive response that is important for cellular homeostasis. We recently discovered another example of lysosomal signaling where lysosomal calcium release activates the master autophagy regulator TFEB via the phosphatase calcineurin.
Lysosomal calcium regulates autophagy / MEDINA SANABRIA, Diego Luis; Ballabio, A. - In: AUTOPHAGY. - ISSN 1554-8627. - 11:6(2015), pp. 970-971. [10.1080/15548627.2015.1047130]
Lysosomal calcium regulates autophagy.
Medina Diego Luis;Ballabio A
2015
Abstract
Recent evidence has indicated that the lysosome is able to act as a signaling organelle that senses nutrient availability and generates an adaptive response that is important for cellular homeostasis. We recently discovered another example of lysosomal signaling where lysosomal calcium release activates the master autophagy regulator TFEB via the phosphatase calcineurin.File in questo prodotto:
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