The chemistry of Rhenium(I) has assumed recently an important role for the synthesis of 186,188Re radiopharmaceuticals. Furthermore, the spectral properties of Rhenium(I) tricarbonyl complexes have been demonstrated to have applications as fluorochromes in fluorescence microscopy. The organometallic complex fac-[Re(H2O)3(CO)3]+ is taken into account due to its simple synthesis and its complexing properties towards biological molecules. Although numerous studies have been carried out on complexes with organic ligands in the solid state, there is little information on the speciation of Rhenium(I) in aqueous solution. By the presence of histidine residues in many biological systems, this work concerns the complexation of the Re(CO)3+ core with histidine in solutions 0.1 M NaClO4, at 25°C by potentiometric measurements by a glass electrode in the range of pH 2-10. Order to do this is necessary to establish hydrolytic equilibria of tricabonyl Rhenium(I). Data processing suggests the formation of the two hydrolytic species: Re(OH)(CO)3 and Re(OH)2(CO)3.

Interaction between fac-[Re(H2O)3(CO)3]+ ion and histidine in aqueous solution / DE TOMMASO, Gaetano; Iuliano, Mauro; Veronica, Celentano; Luca Domenico, D’Andrea; Carla, Isernia; Gaetano, Malgieri. - (2014), pp. 97-98. (Intervento presentato al convegno International Symposium on Metal Complexes (8/12 June - Pavia) tenutosi a Pavia nel 8/12 June 2014).

Interaction between fac-[Re(H2O)3(CO)3]+ ion and histidine in aqueous solution

DE TOMMASO, GAETANO;IULIANO, MAURO;
2014

Abstract

The chemistry of Rhenium(I) has assumed recently an important role for the synthesis of 186,188Re radiopharmaceuticals. Furthermore, the spectral properties of Rhenium(I) tricarbonyl complexes have been demonstrated to have applications as fluorochromes in fluorescence microscopy. The organometallic complex fac-[Re(H2O)3(CO)3]+ is taken into account due to its simple synthesis and its complexing properties towards biological molecules. Although numerous studies have been carried out on complexes with organic ligands in the solid state, there is little information on the speciation of Rhenium(I) in aqueous solution. By the presence of histidine residues in many biological systems, this work concerns the complexation of the Re(CO)3+ core with histidine in solutions 0.1 M NaClO4, at 25°C by potentiometric measurements by a glass electrode in the range of pH 2-10. Order to do this is necessary to establish hydrolytic equilibria of tricabonyl Rhenium(I). Data processing suggests the formation of the two hydrolytic species: Re(OH)(CO)3 and Re(OH)2(CO)3.
2014
Interaction between fac-[Re(H2O)3(CO)3]+ ion and histidine in aqueous solution / DE TOMMASO, Gaetano; Iuliano, Mauro; Veronica, Celentano; Luca Domenico, D’Andrea; Carla, Isernia; Gaetano, Malgieri. - (2014), pp. 97-98. (Intervento presentato al convegno International Symposium on Metal Complexes (8/12 June - Pavia) tenutosi a Pavia nel 8/12 June 2014).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/587681
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