We report a crystallographic and computational analysis of two mutant forms of the Alicyclobacillus acidocaldarius thioredoxin (BacTrx) done in order to evaluate the contribution of two specific amino acids to the thermostability of BacTrx. Our results suggest that the thermostability of BacTrx may be modulated by mutations affecting the overall electrostatic energy of the protein.

AN INTEGRATED STRUCTURAL AND COMPUTATIONAL STUDY ON THE THERMOSTABILITY OF TWO THIOREDOXIN MUTANTS FROM ALICYCLOBACILLUS ACIDOCALDARIUS / Bartolucci, Simonetta; Galdiero, Stefania; R., Improta; V. MENCHISE C., Pedone; E., Pedone; M., Saviano. - In: JOURNAL OF BACTERIOLOGY. - ISSN 0021-9193. - STAMPA. - 185:14(2003), pp. 4285-4289. [10.1128/JB.185.14.4285–4289.2003]

AN INTEGRATED STRUCTURAL AND COMPUTATIONAL STUDY ON THE THERMOSTABILITY OF TWO THIOREDOXIN MUTANTS FROM ALICYCLOBACILLUS ACIDOCALDARIUS

BARTOLUCCI, SIMONETTA;GALDIERO, STEFANIA;
2003

Abstract

We report a crystallographic and computational analysis of two mutant forms of the Alicyclobacillus acidocaldarius thioredoxin (BacTrx) done in order to evaluate the contribution of two specific amino acids to the thermostability of BacTrx. Our results suggest that the thermostability of BacTrx may be modulated by mutations affecting the overall electrostatic energy of the protein.
2003
AN INTEGRATED STRUCTURAL AND COMPUTATIONAL STUDY ON THE THERMOSTABILITY OF TWO THIOREDOXIN MUTANTS FROM ALICYCLOBACILLUS ACIDOCALDARIUS / Bartolucci, Simonetta; Galdiero, Stefania; R., Improta; V. MENCHISE C., Pedone; E., Pedone; M., Saviano. - In: JOURNAL OF BACTERIOLOGY. - ISSN 0021-9193. - STAMPA. - 185:14(2003), pp. 4285-4289. [10.1128/JB.185.14.4285–4289.2003]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/5673
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