Investigations of heterochiral oligodeoxynucleotides 50-TD1GD2GD3- 30-30-GL3GL2TL1-50 (L33) and 30-TD1GD2GD3-50-50-GL3GL2TL1-30 (L55) forming quadruplex structures are reported. Data indicate the presence of enantiomeric left- and right-handed quadruplex helices. In the case of L55, NMR experiments point to an unusual equilibrium between them.

A novel equilibrium relating to the helix handedness in G-quadruplexes formed by heterochiral oligonucleotides with an inversion of polarity site / Virgilio, Antonella; Esposito, Veronica; Mangoni, Alfonso; Mayol, Luciano; Galeone, Aldo. - In: CHEMICAL COMMUNICATIONS. - ISSN 1364-548X. - 49:72(2013), pp. 7935-7937. [10.1039/c3cc44607g]

A novel equilibrium relating to the helix handedness in G-quadruplexes formed by heterochiral oligonucleotides with an inversion of polarity site

VIRGILIO, ANTONELLA;ESPOSITO, VERONICA;MANGONI, ALFONSO;MAYOL, LUCIANO;GALEONE, ALDO
2013

Abstract

Investigations of heterochiral oligodeoxynucleotides 50-TD1GD2GD3- 30-30-GL3GL2TL1-50 (L33) and 30-TD1GD2GD3-50-50-GL3GL2TL1-30 (L55) forming quadruplex structures are reported. Data indicate the presence of enantiomeric left- and right-handed quadruplex helices. In the case of L55, NMR experiments point to an unusual equilibrium between them.
2013
A novel equilibrium relating to the helix handedness in G-quadruplexes formed by heterochiral oligonucleotides with an inversion of polarity site / Virgilio, Antonella; Esposito, Veronica; Mangoni, Alfonso; Mayol, Luciano; Galeone, Aldo. - In: CHEMICAL COMMUNICATIONS. - ISSN 1364-548X. - 49:72(2013), pp. 7935-7937. [10.1039/c3cc44607g]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/563251
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