Mutations in the parkin gene (PARK2) are the most frequent cause of autosomal recessive early-onset Parkinson disease. We performed a transcranial magnetic stimulation study in four patients with parkin mutations. Two patients had a prolonged central motor conduction time at both upper and lower limb, one only at the arm and one only at the leg. The MEP threshold was increased in one patient for the arm and in two for the leg. The MEP amplitude was reduced in one and central silent period shortened in two. The findings demonstrate corticospinal dysfunction in these patients and suggest that the extent of central nervous system involvement in parkin disease may be wider that hitherto supposed.

Neurophysiological evidence of corticospinal tract abnormality in patients with Parkin mutations / DE ROSA, Anna; G., Volpe; L., Marcantonio; Santoro, Lucio; A., Brice; Filla, Alessandro; Perretti, ANNA CARMELA AGNESE; DE MICHELE, Giuseppe. - In: JOURNAL OF NEUROLOGY. - ISSN 0340-5354. - ELETTRONICO. - 253:(2006), pp. 275-279. [10.1007/s00415-006-0096-0]

Neurophysiological evidence of corticospinal tract abnormality in patients with Parkin mutations.

DE ROSA, ANNA;SANTORO, LUCIO;FILLA, ALESSANDRO;PERRETTI, ANNA CARMELA AGNESE;DE MICHELE, GIUSEPPE
2006

Abstract

Mutations in the parkin gene (PARK2) are the most frequent cause of autosomal recessive early-onset Parkinson disease. We performed a transcranial magnetic stimulation study in four patients with parkin mutations. Two patients had a prolonged central motor conduction time at both upper and lower limb, one only at the arm and one only at the leg. The MEP threshold was increased in one patient for the arm and in two for the leg. The MEP amplitude was reduced in one and central silent period shortened in two. The findings demonstrate corticospinal dysfunction in these patients and suggest that the extent of central nervous system involvement in parkin disease may be wider that hitherto supposed.
2006
Neurophysiological evidence of corticospinal tract abnormality in patients with Parkin mutations / DE ROSA, Anna; G., Volpe; L., Marcantonio; Santoro, Lucio; A., Brice; Filla, Alessandro; Perretti, ANNA CARMELA AGNESE; DE MICHELE, Giuseppe. - In: JOURNAL OF NEUROLOGY. - ISSN 0340-5354. - ELETTRONICO. - 253:(2006), pp. 275-279. [10.1007/s00415-006-0096-0]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/483787
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