The ultrastructural morphology of the early phases of mycelium-yeast transition in Histoplasma capsulatum after a temperature shift from 25-degrees-C to only 34-degrees-C is described. Under this condition of lower temperature oxidative phosphorylation is not completely uncoupled and maximum production of heat shock proteins (hsp) occurs. 24 h after temperature shift more than 90% of the cells still appear vital. Alterations in the organization of the mitochondrial cristae are the only ultrastructural changes observed in these cells. In contrast, 70% of the cells degenerate 24 h after a temperature shift from 25-degrees-C to 37-degrees-C and in the remaining cells mitochondria are rarely observed. These observations are discussed in relation to the production of hsp, the uncoupling of oxidative phosphorylation and the virulence of different strains of H. capsulatum.

The Effect of Temperature On the Ultrastructure of Histoplasma-capsulatum During the Mycelium-yeast Transition / Borgia, Guglielmo; A., Tallarino; J., Crowell; A., Lambiase; S., Cicciarello; L., Reynaud; G., Nasti; M., Piazza. - In: MYCOSES. - ISSN 0933-7407. - STAMPA. - 33:(1990), pp. 405-410.

The Effect of Temperature On the Ultrastructure of Histoplasma-capsulatum During the Mycelium-yeast Transition

BORGIA, GUGLIELMO;
1990

Abstract

The ultrastructural morphology of the early phases of mycelium-yeast transition in Histoplasma capsulatum after a temperature shift from 25-degrees-C to only 34-degrees-C is described. Under this condition of lower temperature oxidative phosphorylation is not completely uncoupled and maximum production of heat shock proteins (hsp) occurs. 24 h after temperature shift more than 90% of the cells still appear vital. Alterations in the organization of the mitochondrial cristae are the only ultrastructural changes observed in these cells. In contrast, 70% of the cells degenerate 24 h after a temperature shift from 25-degrees-C to 37-degrees-C and in the remaining cells mitochondria are rarely observed. These observations are discussed in relation to the production of hsp, the uncoupling of oxidative phosphorylation and the virulence of different strains of H. capsulatum.
1990
The Effect of Temperature On the Ultrastructure of Histoplasma-capsulatum During the Mycelium-yeast Transition / Borgia, Guglielmo; A., Tallarino; J., Crowell; A., Lambiase; S., Cicciarello; L., Reynaud; G., Nasti; M., Piazza. - In: MYCOSES. - ISSN 0933-7407. - STAMPA. - 33:(1990), pp. 405-410.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/483359
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