The suppressors of cytokine signaling (SOCS) are recently identified inhibitors of cytokine and growth factor signaling that act via the Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathways. Aberrant Jak/STAT signaling promotes progression from hypertrophy to heart failure. Little information is available concerning the role of SOCS in the transition from hypertrophy to heart failure. To this aim, we investigated the effects of SOCS-1 overexpression obtained by adeno-associated gene transfer in a chronic pressure-overload cardiac rat model.
SOCS-1 GENE TRANSFER ACCELERATES THE TRANSITION TO HEART FAILURE THROUGH THE INHIBITION OF THE GP130/JAK/STAT PATHWAY IN A CHRONIC PRESSURE-OVERLOADED RAT MODEL / Cittadini, Antonio; Monti, MARIA GAIA; Chiacchio, M.; Salzano, Andrea; Bobbio, Emanuele; Longobardi, S.; Saldamarco, Lavinia; Baldi, A.; Petrillo, V.; Condorelli, G.. - (2011). (Intervento presentato al convegno HEART FAILURE 2011 tenutosi a GOTHENBURG - SWEDEN nel 21-24 MAGGIO 2011).
SOCS-1 GENE TRANSFER ACCELERATES THE TRANSITION TO HEART FAILURE THROUGH THE INHIBITION OF THE GP130/JAK/STAT PATHWAY IN A CHRONIC PRESSURE-OVERLOADED RAT MODEL
CITTADINI, ANTONIO;MONTI, MARIA GAIA;SALZANO, ANDREA;BOBBIO, EMANUELE;SALDAMARCO, LAVINIA;
2011
Abstract
The suppressors of cytokine signaling (SOCS) are recently identified inhibitors of cytokine and growth factor signaling that act via the Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathways. Aberrant Jak/STAT signaling promotes progression from hypertrophy to heart failure. Little information is available concerning the role of SOCS in the transition from hypertrophy to heart failure. To this aim, we investigated the effects of SOCS-1 overexpression obtained by adeno-associated gene transfer in a chronic pressure-overload cardiac rat model.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
