Oxygen consumption at peak exercise(peak VO2)is a strong independent predictor of the outcome in congestive heart failure(CHF). RAS inhibition with either ACE or ARB is effective on peak VO2. We evaluated whether mechanisms are similar for the 2 categories of drugs and whether their combination is able to produce a synergistic effect.in the multivariate Cox regression analysis, N, peak VO2 and exercise performance during bicycling and walking tests had prognostic significance in elderly hypertensives with CHF treated with ARB in addition to ACE. For pts unable to tolerate an ACE inhibitor the use of an ARB may confer same advantage
SYNERGISTIC EFFICACY OF OLMESARTAN AND BENAZEPRIL ON EXERCISE PERFORMANCE AND OXYGEN CONSUMPTION AT PEAK EXERCISE IN CONGESTIVE HEART FAILURE IN ELDERLY HYPERTENSIVE PATIENTS / DE ROSA, MARIA LEONARDA. - In: JOURNAL OF HYPERTENSION. - ISSN 0263-6352. - STAMPA. - 28:e 49 Suppl A(2010), pp. e49 (PP.1.09)-e49 (PP.1.09). [10.1097/01.hjh.0000378333.64381.b1]
SYNERGISTIC EFFICACY OF OLMESARTAN AND BENAZEPRIL ON EXERCISE PERFORMANCE AND OXYGEN CONSUMPTION AT PEAK EXERCISE IN CONGESTIVE HEART FAILURE IN ELDERLY HYPERTENSIVE PATIENTS
DE ROSA, MARIA LEONARDA
2010
Abstract
Oxygen consumption at peak exercise(peak VO2)is a strong independent predictor of the outcome in congestive heart failure(CHF). RAS inhibition with either ACE or ARB is effective on peak VO2. We evaluated whether mechanisms are similar for the 2 categories of drugs and whether their combination is able to produce a synergistic effect.in the multivariate Cox regression analysis, N, peak VO2 and exercise performance during bicycling and walking tests had prognostic significance in elderly hypertensives with CHF treated with ARB in addition to ACE. For pts unable to tolerate an ACE inhibitor the use of an ARB may confer same advantageI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
