Two novel pentacyclic guanidine alkaloids, celeromycalin 3 and fromiamycalin 4, have been isolated from the New Caledonian starfishes Celerina heffernani and Fromia monilis, respectively. The new compounds exhibited an high cytotoxic activity like the previous crambescidins. These complex pentacyclic guanidines are typical sponges metabolites and their occurence in starfishes is noteworthy. Fromia monilis also contained the less active component 5, made up from an hydroxyspermidine residue linked to a long chain omega-hydroxyacid.
Ptilomycalin A, crambescidin 800 and related new highly cytotoxic guanidine alkaloids from starfishes Fromia monilis and Celerina heffernani / E., Palagiano; DE MARINO, Simona; L., Minale; R., Riccio; M., Iorizzi; Zollo, Franco; J. B., Carrè; J., Provost. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 51:12(1995), pp. 3675-3682. [10.1016/0040-4020(95)00082-J]
Ptilomycalin A, crambescidin 800 and related new highly cytotoxic guanidine alkaloids from starfishes Fromia monilis and Celerina heffernani
DE MARINO, SIMONA;ZOLLO, FRANCO;
1995
Abstract
Two novel pentacyclic guanidine alkaloids, celeromycalin 3 and fromiamycalin 4, have been isolated from the New Caledonian starfishes Celerina heffernani and Fromia monilis, respectively. The new compounds exhibited an high cytotoxic activity like the previous crambescidins. These complex pentacyclic guanidines are typical sponges metabolites and their occurence in starfishes is noteworthy. Fromia monilis also contained the less active component 5, made up from an hydroxyspermidine residue linked to a long chain omega-hydroxyacid.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
