The high red blood cell (RBC) deformability observed in vivo is essential to ensure optimal gas exchange between gas and tissues in microcirculation. Here, we focus on RBC flow behavior in microconned geometries in vitro, such as circular section capillaries, rectangular channels and pores, where at least one transverse dimension is comparable to cell size. Experimental results on RBC velocity and shape are reviewed together with modeling predictions and numerical simulations. A comparison with model systems, such as droplets and vesicles, is also presented. In spite of the progress made so far, the physiopathological implications of altered RBC deformability are still to be fully elucidated, and more data from clinically-relevant experimental methods and modeling-based interpretation are needed. Future directions include the emerging application of microfluidics techniques to investigate RBC flow in complex geometries.

Flow behavior of red blood cells in confined geometries / Guido, Stefano. - (2009). (Intervento presentato al convegno Softflow 2009 Complex- and bio-fluids tenutosi a Cargese nel 22 giugno - 4 luglio 2009).

Flow behavior of red blood cells in confined geometries

GUIDO, STEFANO
2009

Abstract

The high red blood cell (RBC) deformability observed in vivo is essential to ensure optimal gas exchange between gas and tissues in microcirculation. Here, we focus on RBC flow behavior in microconned geometries in vitro, such as circular section capillaries, rectangular channels and pores, where at least one transverse dimension is comparable to cell size. Experimental results on RBC velocity and shape are reviewed together with modeling predictions and numerical simulations. A comparison with model systems, such as droplets and vesicles, is also presented. In spite of the progress made so far, the physiopathological implications of altered RBC deformability are still to be fully elucidated, and more data from clinically-relevant experimental methods and modeling-based interpretation are needed. Future directions include the emerging application of microfluidics techniques to investigate RBC flow in complex geometries.
2009
Flow behavior of red blood cells in confined geometries / Guido, Stefano. - (2009). (Intervento presentato al convegno Softflow 2009 Complex- and bio-fluids tenutosi a Cargese nel 22 giugno - 4 luglio 2009).
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/368745
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact