The potential anxiolytic and anti-depressive activity of CMP1 was studied in the elevated plus-maze test and in the forced swimming test. Furthermore, CMP1 sedative activity was evaluated in pentobarbital treated animals; the effect of CMP1 on spontaneous motor activity (total locomotion) was also evaluated. Our data show that CMP1, at doses that did not affect locomotion, was able to induce anxiolytic and sedative, but not anti-depressive effects. In conclusion, our results represent first evidence for an anxiolytic activity of this diterpenoid from Salvia cinnabarina.
First evidence for an anxiolitic effect of a diterpenoid from Salvia cinnabarina / Maione, Francesco; Bonito, Mc; Colucci, M; Cozzolino, V; Bisio, A; Romussi, G; Cicala, Carla; Pieretti, S; Mascolo, NICOLA DOMENICO C. FERDINANDO. - In: NATURAL PRODUCT COMMUNICATIONS. - ISSN 1934-578X. - STAMPA. - 4:4(2009), pp. 469-472.
First evidence for an anxiolitic effect of a diterpenoid from Salvia cinnabarina
MAIONE, FRANCESCO;CICALA, CARLA;MASCOLO, NICOLA DOMENICO C. FERDINANDO
2009
Abstract
The potential anxiolytic and anti-depressive activity of CMP1 was studied in the elevated plus-maze test and in the forced swimming test. Furthermore, CMP1 sedative activity was evaluated in pentobarbital treated animals; the effect of CMP1 on spontaneous motor activity (total locomotion) was also evaluated. Our data show that CMP1, at doses that did not affect locomotion, was able to induce anxiolytic and sedative, but not anti-depressive effects. In conclusion, our results represent first evidence for an anxiolytic activity of this diterpenoid from Salvia cinnabarina.File | Dimensione | Formato | |
---|---|---|---|
Maione et al., 2009 NPC.pdf
accesso aperto
Descrizione: First Evidence for an Anxiolytic Effect of a Diterpenoid from Salvia cinnabarina
Tipologia:
Documento in Post-print
Licenza:
Accesso privato/ristretto
Dimensione
268.76 kB
Formato
Adobe PDF
|
268.76 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.