We describe an MDS patient showing neutropenia, CD14+CD56+ monocytosis and polyclonal expansion of NK cells. A defective HLA-E expression on myeloid lineage, the constitutive presence of CD178 on the CD14+CD56+ monocytes combined with expansion of CD94/NKG2A+ CD94/NKG2C+ NK cells are proposed to be relevant for the pathogenesis of this haematopoietic disorder
A Case of Myelodysplastic syndrome associated with CD14+CD56+ monocytosis, expansion of NK lymphocytes and defect of HLA-E expression / Ruggiero, Giuseppina; Sica, M.; Luciano, L.; Savoia, F.; Cosentini, Elena; Alfinito, Fiorella; Terrazzano, G.. - In: LEUKEMIA RESEARCH. - ISSN 0145-2126. - STAMPA. - 33:1(2009), pp. 181-185.
A Case of Myelodysplastic syndrome associated with CD14+CD56+ monocytosis, expansion of NK lymphocytes and defect of HLA-E expression
RUGGIERO, GIUSEPPINA;COSENTINI, ELENA;ALFINITO, FIORELLA;
2009
Abstract
We describe an MDS patient showing neutropenia, CD14+CD56+ monocytosis and polyclonal expansion of NK cells. A defective HLA-E expression on myeloid lineage, the constitutive presence of CD178 on the CD14+CD56+ monocytes combined with expansion of CD94/NKG2A+ CD94/NKG2C+ NK cells are proposed to be relevant for the pathogenesis of this haematopoietic disorder| File | Dimensione | Formato | |
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