A research program has been initiated in 1990 to carefully examine the toxin profiles in mussels from Northern Adriatic sea. Since then, a number of polyether toxins have been isolated and characterized, some of which represent new additions to the DSP-class of biotoxins and seem to be peculiar of Adriatic sea. During our investigation on toxic Adriatic mussels we have also isolated new type of toxins, whose structure was elucidated by extensive use of 1D and 2D NMR techniques. Some of them could represent a further alarm for the public health due to their cytotoxic activity. The recent application of LC-MS methods for detection of Adriatic marine biotoxins allowed to fasten the analysis of toxic samples and to advance effective structural hypothesis even when full structure elucidation of new toxins by NMR spectroscopy is hampered by the limited amount of available material.
Toxins from Adriatic Blue mussels: a decade of studies / Ciminiello, Patrizia; Dell'Aversano, Carmela; Fattorusso, Ernesto; Forino, Martino; S., Magno. - In: PURE AND APPLIED CHEMISTRY. - ISSN 0033-4545. - STAMPA. - 75:(2003), pp. 325-336. [10.1351/pac200375020325]
Toxins from Adriatic Blue mussels: a decade of studies
CIMINIELLO, PATRIZIA;DELL'AVERSANO, CARMELA;FATTORUSSO, ERNESTO;FORINO, MARTINO;
2003
Abstract
A research program has been initiated in 1990 to carefully examine the toxin profiles in mussels from Northern Adriatic sea. Since then, a number of polyether toxins have been isolated and characterized, some of which represent new additions to the DSP-class of biotoxins and seem to be peculiar of Adriatic sea. During our investigation on toxic Adriatic mussels we have also isolated new type of toxins, whose structure was elucidated by extensive use of 1D and 2D NMR techniques. Some of them could represent a further alarm for the public health due to their cytotoxic activity. The recent application of LC-MS methods for detection of Adriatic marine biotoxins allowed to fasten the analysis of toxic samples and to advance effective structural hypothesis even when full structure elucidation of new toxins by NMR spectroscopy is hampered by the limited amount of available material.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
