Background & Aims: Celiac disease (CD) has been associated with several genetic disorders, but has not been associated with hereditary fructose intolerance (HFI). Methods: We identified CD in 4 female patients affected by HFI from among 38 Italian HFI patients. Results: Three of these patients were children in whom the CD-associated signs were hypertransaminasemia, failure to thrive, low weight, and short stature, whereas the adult patient had protracted diarrhea notwithstanding a fructose-free diet. The incidence of CD in our group of HFI patients was higher (>10%) than in the general population (1%–3%) (P < .02). Conclusions: The possibility of an association between these 2 gastrointestinal disorders is important, particularly in the management of HFI patients with persisting symptoms.
Hereditary fructose intolerance and celiac disease: a novel genetic association / C., Ciacci; D., Gennarelli; Esposito, Gabriella; R., Tortora; Salvatore, Francesco; Sacchetti, Lucia. - In: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. - ISSN 1542-3565. - STAMPA. - 4:5(2006), pp. 635-638. [10.1016/j.cgh.2005.12.004]
Hereditary fructose intolerance and celiac disease: a novel genetic association
ESPOSITO, GABRIELLA;SALVATORE, FRANCESCO;SACCHETTI, LUCIA
2006
Abstract
Background & Aims: Celiac disease (CD) has been associated with several genetic disorders, but has not been associated with hereditary fructose intolerance (HFI). Methods: We identified CD in 4 female patients affected by HFI from among 38 Italian HFI patients. Results: Three of these patients were children in whom the CD-associated signs were hypertransaminasemia, failure to thrive, low weight, and short stature, whereas the adult patient had protracted diarrhea notwithstanding a fructose-free diet. The incidence of CD in our group of HFI patients was higher (>10%) than in the general population (1%–3%) (P < .02). Conclusions: The possibility of an association between these 2 gastrointestinal disorders is important, particularly in the management of HFI patients with persisting symptoms.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.