The present report is an attempt to investigate the influence of intraperitoneal and dietary cadmium exposure on the distribution of cadmium accumulation and induction of metallothionein gene expression in different tissues of the lizard Podarcis sicula. Cadmium accumulation in liver, kidney, ovary, brain and intestine was measured by atomic absorption spectrometry. Metallothionein gene induction was determined by dot blot analyses on the total RNA extracted from the same organs. Our data indicate that cadmium exposure results in significant cadmium uptake, but the patterns of this uptake varies with organ and exposure route. After a single intraperitoneal treatment, concentrations of cadmium and metallothionein transcript are positively correlated in kidney, liver and ovary. Following a dietary cadmium treatment, a positive correlation between the increase of metallothionein mRNA and cadmium accumulation is found in intestine, ovary and kidney, while no correlation is present in liver and brain.

Cadmium distribution and metallothionein expression in lizard tissues following acute and chronic cadmium intoxication / F., Trinchella; M., Riggio; Filosa, Silvana; M. G., Volpe; E., Parisi; Scudiero, Rosaria. - In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. C. TOXICOLOGY & PHARMACOLOGY. - ISSN 1532-0456. - STAMPA. - 144:(2006), pp. 272-278. [10.1016/j.cbpc.2006.09.004]

Cadmium distribution and metallothionein expression in lizard tissues following acute and chronic cadmium intoxication.

FILOSA, SILVANA;SCUDIERO, ROSARIA
2006

Abstract

The present report is an attempt to investigate the influence of intraperitoneal and dietary cadmium exposure on the distribution of cadmium accumulation and induction of metallothionein gene expression in different tissues of the lizard Podarcis sicula. Cadmium accumulation in liver, kidney, ovary, brain and intestine was measured by atomic absorption spectrometry. Metallothionein gene induction was determined by dot blot analyses on the total RNA extracted from the same organs. Our data indicate that cadmium exposure results in significant cadmium uptake, but the patterns of this uptake varies with organ and exposure route. After a single intraperitoneal treatment, concentrations of cadmium and metallothionein transcript are positively correlated in kidney, liver and ovary. Following a dietary cadmium treatment, a positive correlation between the increase of metallothionein mRNA and cadmium accumulation is found in intestine, ovary and kidney, while no correlation is present in liver and brain.
2006
Cadmium distribution and metallothionein expression in lizard tissues following acute and chronic cadmium intoxication / F., Trinchella; M., Riggio; Filosa, Silvana; M. G., Volpe; E., Parisi; Scudiero, Rosaria. - In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. C. TOXICOLOGY & PHARMACOLOGY. - ISSN 1532-0456. - STAMPA. - 144:(2006), pp. 272-278. [10.1016/j.cbpc.2006.09.004]
File in questo prodotto:
File Dimensione Formato  
CBP-C(2006).pdf

non disponibili

Tipologia: Documento in Post-print
Licenza: Accesso privato/ristretto
Dimensione 755.47 kB
Formato Adobe PDF
755.47 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/203660
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 55
  • ???jsp.display-item.citation.isi??? 51
social impact