New solid supports, linking protected pyrimidine and purine nucleoside derivatives through the nucleobase, have been prepared. The support incorporating a suitable derivative of 2’-azido, 2’-deoxyuridine allowed the simple and efficient solid -phase synthesis of ribose-modified nucleoside and nucleic acid analogues, particularly of aminoacyl derivatives of 2’-deoxy, 2’-amino-uridine, following methodologies well established in peptide and oligonucleotide chemistry.
NEW NUCLEOSIDE-BASED POLYMERIC SUPPORT FOR THE SOLID PHASE SYNTHESIS OF RIBOSE-MODIFIED NUCLEOSIDE ANALOGUES / DE NAPOLI, Lorenzo; DI FABIO, Giovanni; J., D'Onofrio; Montesarchio, Daniela. - In: SYNLETT. - ISSN 0936-5214. - ELETTRONICO. - 11:(2004), pp. 1975-1979. [10.1055/s-2004-830864]
NEW NUCLEOSIDE-BASED POLYMERIC SUPPORT FOR THE SOLID PHASE SYNTHESIS OF RIBOSE-MODIFIED NUCLEOSIDE ANALOGUES
DE NAPOLI, LORENZO;DI FABIO, GIOVANNI;MONTESARCHIO, DANIELA
2004
Abstract
New solid supports, linking protected pyrimidine and purine nucleoside derivatives through the nucleobase, have been prepared. The support incorporating a suitable derivative of 2’-azido, 2’-deoxyuridine allowed the simple and efficient solid -phase synthesis of ribose-modified nucleoside and nucleic acid analogues, particularly of aminoacyl derivatives of 2’-deoxy, 2’-amino-uridine, following methodologies well established in peptide and oligonucleotide chemistry.| File | Dimensione | Formato | |
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