Common fragile sites can be damaged by exposure to a variety of carcinogens. The fragile histidine triad (FHIT) gene, including the most active human chromosomal fragile site (FRA3B) at chromosome band HSA3p14.2,1 has been proposed as a tumour suppressor gene for a variety of tumours.2 The most common response to carcinogen exposure is deletions at the FHIT locus that alter the gene structure and function. In this study we assign the FHIT gene in cattle, river buffalo, sheep and goat chromosomes by comparative fluorescence in situ hybridization (FISH)-mapping. In addition, the assignment to BTA22 was confirmed by typing the marker across a bovine radiation hybrid (RH) panel.
Comparative mapping of the fragile histidine triad (FHIT) gene in cattle, river buffalo, sheep and goat by FISH and assignment to BTA22 by RH-mapping: a comparison with HSA3 / G. P., Di Meo; A., Perucatti; C., Uboldi; Roperto, Sante; D., Incarnato; Roperto, FRANCO PEPPINO; J., Williams; A., Eggen; L., Ferretti; L., Iannuzzi. - In: ANIMAL GENETICS. - ISSN 0268-9146. - STAMPA. - 36:4(2005), pp. 363-364. [10.1111/j.1365-2052.2005.01319.x]
Comparative mapping of the fragile histidine triad (FHIT) gene in cattle, river buffalo, sheep and goat by FISH and assignment to BTA22 by RH-mapping: a comparison with HSA3
ROPERTO, SANTE;ROPERTO, FRANCO PEPPINO;
2005
Abstract
Common fragile sites can be damaged by exposure to a variety of carcinogens. The fragile histidine triad (FHIT) gene, including the most active human chromosomal fragile site (FRA3B) at chromosome band HSA3p14.2,1 has been proposed as a tumour suppressor gene for a variety of tumours.2 The most common response to carcinogen exposure is deletions at the FHIT locus that alter the gene structure and function. In this study we assign the FHIT gene in cattle, river buffalo, sheep and goat chromosomes by comparative fluorescence in situ hybridization (FISH)-mapping. In addition, the assignment to BTA22 was confirmed by typing the marker across a bovine radiation hybrid (RH) panel.File | Dimensione | Formato | |
---|---|---|---|
AnimGenet.pdf
accesso aperto
Tipologia:
Altro materiale allegato
Licenza:
Dominio pubblico
Dimensione
103.94 kB
Formato
Adobe PDF
|
103.94 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.