Innexins are a family of transmembrane proteins involved in the formation of gap junctions, specific intercellular channels, in invertebrates. Analyses of the entire innexin family during Drosophila melanogaster embryonic development shows the occurrence of complex and specific patterns of expression of the different genes. Innexins inx-2 and inx-7, in general, do not appear to exhibit extensive co-expression in different D. melanogaster cellular compartments. We propose here a new and robust mechanism, based on our analysis of the genomic organization of inx-2 and inx-7, that structurally justifies the reciprocal expression of genes. (Corresponding author)
A possible flip-flop genetic mechanism for reciprocal gene expression / Chiusano, MARIA LUISA; DI GIAIMO, Rossella; Potenza, Nicoletta; Russo, G. M. R.; Geraci, Giuseppe; DEL GAUDIO, Rosanna. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 579:(2005), pp. 4919-4922.
A possible flip-flop genetic mechanism for reciprocal gene expression.
CHIUSANO, MARIA LUISA;DI GIAIMO, ROSSELLA;POTENZA, Nicoletta;GERACI, GIUSEPPE;DEL GAUDIO, ROSANNA
2005
Abstract
Innexins are a family of transmembrane proteins involved in the formation of gap junctions, specific intercellular channels, in invertebrates. Analyses of the entire innexin family during Drosophila melanogaster embryonic development shows the occurrence of complex and specific patterns of expression of the different genes. Innexins inx-2 and inx-7, in general, do not appear to exhibit extensive co-expression in different D. melanogaster cellular compartments. We propose here a new and robust mechanism, based on our analysis of the genomic organization of inx-2 and inx-7, that structurally justifies the reciprocal expression of genes. (Corresponding author)I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
