Mortality related to heart rate (HR) increase in the elderly has not yet been well established.Toascertain the relationshipsamong cognitiveimpairment (CI), mortality, and HR increase, the authors prospectively studied a random sample of elderly subjects stratified according to presence or absence of CI. Elderly subjects randomly selected in 1991 (n ¼ 1332) were followed up for 12 years. Mortality was established in 98.1% of the subjects. When HRwas stratifiedinquartiles (<69,70–75,76–80,and >80 bpm),mortality was linearly associated with increasedHRin all (from47.7 to 57.0; r2 ¼ .43, p ¼ .019) and in subjects without (from41.7 to 51.1%; r2 ¼ .50, p ¼ .043) but not in those with CI (from 57.5 to 66.1; r2 ¼ .20, p ¼ .363). Cox regression analysis, adjusted for several variables, shows that HR doesn’t predict mortality in all subjects (RR 0.69; 95% CI ¼ 0.27–1.73) or in those with CI (RR 0.91; 95% CI ¼ 0.81–1.02). In contrast, HR predicts mortality in subjects without CI (RR 1.10; 95% CI ¼ 1.00–1.22). Hence, HR increase is a predictor of mortality in elderly subjects without CI. However, when considering all elderly subjects and those with CI, HR increase seems to have no effect on mortality. Thus, CI should be considered when focusing onHRincrease as risk factor formortality in the elderly.

Mortality and heart rate in the elderly: role of cognitive impairment / Cacciatore, F; Mazzella, F; Abete, Pasquale; Viati, L; Galizia, G; D'Ambrosio, D; Gargiulo, G; Russo, S; Visconti, C; DELLA MORTE, D; Ferrara, Nicola; Rengo, Franco. - In: EXPERIMENTAL AGING RESEARCH. - ISSN 0361-073X. - ELETTRONICO. - 33:(2007), pp. 127-144.

Mortality and heart rate in the elderly: role of cognitive impairment.

CACCIATORE F;ABETE, PASQUALE;FERRARA, NICOLA;RENGO, FRANCO
2007

Abstract

Mortality related to heart rate (HR) increase in the elderly has not yet been well established.Toascertain the relationshipsamong cognitiveimpairment (CI), mortality, and HR increase, the authors prospectively studied a random sample of elderly subjects stratified according to presence or absence of CI. Elderly subjects randomly selected in 1991 (n ¼ 1332) were followed up for 12 years. Mortality was established in 98.1% of the subjects. When HRwas stratifiedinquartiles (<69,70–75,76–80,and >80 bpm),mortality was linearly associated with increasedHRin all (from47.7 to 57.0; r2 ¼ .43, p ¼ .019) and in subjects without (from41.7 to 51.1%; r2 ¼ .50, p ¼ .043) but not in those with CI (from 57.5 to 66.1; r2 ¼ .20, p ¼ .363). Cox regression analysis, adjusted for several variables, shows that HR doesn’t predict mortality in all subjects (RR 0.69; 95% CI ¼ 0.27–1.73) or in those with CI (RR 0.91; 95% CI ¼ 0.81–1.02). In contrast, HR predicts mortality in subjects without CI (RR 1.10; 95% CI ¼ 1.00–1.22). Hence, HR increase is a predictor of mortality in elderly subjects without CI. However, when considering all elderly subjects and those with CI, HR increase seems to have no effect on mortality. Thus, CI should be considered when focusing onHRincrease as risk factor formortality in the elderly.
2007
Mortality and heart rate in the elderly: role of cognitive impairment / Cacciatore, F; Mazzella, F; Abete, Pasquale; Viati, L; Galizia, G; D'Ambrosio, D; Gargiulo, G; Russo, S; Visconti, C; DELLA MORTE, D; Ferrara, Nicola; Rengo, Franco. - In: EXPERIMENTAL AGING RESEARCH. - ISSN 0361-073X. - ELETTRONICO. - 33:(2007), pp. 127-144.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/201666
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